This course provides instruction in the pathological processes that affect the body’s organ systems and establishes the foundational knowledge necessary for subsequent coursework in the Clinical Medicine series. Students will examine the mechanical, biochemical, cellular, and physiological mechanisms underlying human disease, with emphasis on clinical relevance. Topics include epidemiology, etiology, pathophysiology/pathogenesis, and the resulting clinical presentations of disease states. Instruction integrates course content, videos, lectures, discussions, and formative assignments to reinforce learning. The course begins with foundational concepts in cell injury, cell death, and tissue repair and progresses through a systems-based approach to disease. Content in this course serves as the essential framework for Clinical Medicine II and Clinical Medicine III.