This is part I of a 2-course series in musculoskeletal physical therapy. Learners will begin to build a foundation in orthopedic examination and intervention based on the elements of patient/client management (Guide to Physical Therapist Practice) for the cervical spine, temporomandibular joint, head/face, thoracic spine and upper extremity. Patient cases will be used to teach the learner about physical therapy management of musculoskeletal conditions across the continuum of care and throughout the lifespan. Learners will be introduced to musculoskeletal differential diagnosis, regional interdependence, and will utilize clinical decision making in patient scenarios. Management of the patient/client will be related to principles of tissue healing, impairments, and knowledge of pathology and pathomechanics. These principles are applied to musculoskeletal dysfunction of the cervical spine, temporomandibular joint, head/face, thoracic spine and upper extremity regions in this course, but also serve as a foundation for future courses in the management of patients with other system- or lifespan-related disorders.