This course provides physician assistant students with focused instruction in the appropriate selection and interpretation of clinical diagnostic testing with emphasis on evidence-based decision-making. The course will also address appropriate referral to specialists for advanced diagnostic evaluation and consultation when care needs extend beyond the scope of primary practice. Course delivery includes assigned readings, online materials, instructional videos, weekly lectures, and class discussions. Formative in-class activities will reinforce critical thinking skills to integrate learned material into clinical decision making. Instruction begins with an introduction to evidence-based medicine concepts and diagnostic testing before progressing to in depth clinical diagnostic in system-based format. Content will be complementary and help reinforce skills and competencies in Clinical Medicine II and Clinical Skills establishing a strong foundation for advanced coursework, clinical rotations, and evidence-based patient care.