This course provides instruction in the pathological processes affecting the body’s organ systems. Students will examine the mechanical, biochemical, cellular, and physiological mechanisms underlying human disease, with emphasis on their clinical relevance. Topics include epidemiology, etiology, pathophysiology/pathogenesis, and the resulting clinical presentations of various disease states. Instruction will integrate links to course content, videos, lectures, discussions, and formative assignments to reinforce learning. The course begins with foundational concepts in cell injury, death, and tissue repair, then proceeds through a system-based approach. Content serves as the essential framework for subsequent Clinical Medicine II and Clinical Medicine III courses.